Anafranil (Clomipramine)

Anafranil is used for treating obsessive-compulsive disorder (OCD). It may also be used for other conditions as determined by your doctor.

Use Anafranil as directed by your doctor.

• Take Anafranil by mouth with food to decrease stomach upset.
• It may take 2 to 3 weeks before you notice the effect of Anafranil . Continue to use Anafranil even if you feel well. Do not miss any doses.

Anafranil is a tricyclic antidepressant. It works by increasing the activity of certain chemicals in the brain, which helps to reduce obsessive-compulsive behaviors.

If you miss a dose of Anafranil, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Anafranil at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Anafranil out of the reach of children and away from pets.

Do not use Anafranil if:

• you are allergic to any ingredient in Anafranil;
• you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (e.g., phenelzine) within the last 14 days, or you are taking astemizole or terfenadine;
• you are recovering from a recent heart attack.

• Anafranil may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Anafranil with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Do not drink alcohol or use medicines that may cause drowsiness (e.g., sleep aids, muscle relaxers) while you are using Anafranil; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
• Anafranil may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
• Do not become overheated in hot weather or while you are being active; heatstroke may occur.
• Children, teenagers, and young adults who take Anafranil may be at increased risk for suicidal thoughts or actions. Watch all patients who take Anafranil closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
• Anafranil may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Anafranil. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Tell your doctor or dentist that you take Anafranil before you receive any medical or dental care, emergency care, or surgery.
• Lab tests, including complete blood cell counts, may be performed while you use Anafranil. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Pregnancy and breast-feeding: It is not known if Anafranil can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Anafranil while you are pregnant. Anafranil is found in breast milk. Do not breast-feed while taking Anafranil.

Check with your doctor if any of these most common side effects persist or become bothersome:

• constipation; diarrhea; dizziness; drowsiness; dry mouth; headache; irritability; loss of appetite; nausea; nightmares; sweating; tiredness; upset stomach; vomiting; weakness; weight loss or gain.

• severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; changes in sex drive; chest pain; confusion; decreased sexual ability; fainting; fast, slow, or irregular heartbeat; fever; flushing; frequent or difficult urination; impulsive behavior or other unusual changes in behavior; mental or mood changes (eg, increased anxiety, mood swings, agitation, irritability, nervousness, restlessness); numbness or tingling of the skin; panic attacks; ringing in the ears; seizures; severe dizziness or drowsiness; sore throat; stomach pain; suicidal thinking or behavior; swelling of the testicles; tremor; trouble sleeping; trouble walking or keeping your balance; twitching of the face or tongue; uncontrolled movements or stiffness of arms and legs; unusual bleeding or bruising; worsening of depression; yellowing of the skin or eyes.

Anafranil is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.